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A combination rune is any rune that takes two types of the elemental runes (fire, earth, air, and water) and combine them, which essentially makes two runes in one. The following combination runes are available in the game:
|Rune||Combination||Runecrafting Level||Equivalent staff|
|Mist rune||Air rune and Water rune||6||Mist battlestaff (Mystic mist staff)|
|Dust rune||Air rune and Earth rune||10||Dust battlestaff (Mystic dust staff)|
|Mud rune||Water rune and Earth rune||13||Mud battlestaff (Mystic mud staff)|
|Smoke rune||Air rune and Fire rune||15||Smoke battlestaff (Mystic smoke staff)|
|Steam rune||Water rune and Fire rune||19||Steam battlestaff (Mystic steam staff)|
|Lava rune||Earth rune and Fire rune||23||Lava battlestaff (Mystic lava staff)|
To make such runes, players need to bring pure essence, an amount of certain elemental runes that is equal to the amount of pure essence, and a talisman to enter the altar they choose (unless accessing the altar via the Abyss). For example, if a player wishes to make 10 steam runes, they could bring one of the following sets of items:
- Ten pure essence, ten Water runes, and a Water talisman to the Fire altar
- Ten pure essence, ten Fire runes, and a Fire talisman to the Water altar.
However, the chance of successfully binding the runes together is only 50%, and the talisman used to make the combination runes is consumed in the process. A worn Necklace of Binding increases this chance of success to 100%, though it can only be used 16 times before it is destroyed.