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Essence could refer to:
- Rune essence, mined at the rune essence mine at below level 30 Mining;
- Pure essence, mined at the rune essence mine at level 30 Mining or above;
- The Rune Essence Mine, accessible after the Rune Mysteries quest;
- Essence impling, an impling caught with at least level 42 in Hunter;
- Essence impling jar, the lootable item obtained as a result of catching an essence impling;
- Magic essence, a potion that can be made during and after Fairy Tale II - Cure a Queen.
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