Rune may refer to:
- Rune equipment, metal equipment made from runite, suitable for melee fighters, a complete set of which is often called "rune set" or "full rune" or sometimes, "rune full".
- Runite ore
- Rune bar
- Runite metal
- Runes, magic stones used for casting spells via the Magic skill.
- RuneScape, the game that may be called "RS" for short.